叔丁酰胺也可当作伯酰胺的替代品，在二氯亚砜，三氯氧磷或草酰氯作用下脱叔丁基脱水为腈，因此有时在制备伯酰胺不容易时，做成相应的叔丁酰胺转化为腈也不失为一个好的方法。

叔丁酰胺脱水为腈示例一

    A solution of 1.240 mmol of N-tert-butyl-4-(6,7-dihydro-5H-[2]pyridin-7-yl)benzamide and 1.0 ml of thionyl chloride in 30 ml of chloroform is stirred under reflux for 6 hours. The reaction mixture is cooled to room temperature and evaporated. The residue is taken up in dichloromethane and mixed with saturated aqueous sodium bicarbonate solution. The organic phase is separated and the aqueous phase is extracted with dichloromethane (2x). The combined organic phases are dried with sodium sulphate and concentrated. The residue

is dissolved in diethyl ether and the title compound is converted into the hydrochloride salt by adding ethereal HCI solution (2N). The solid is stirred in diethyl ether/acetone (1: 1), filtered and dried. The title compound is obtained as a dark grey solid. R f (free base) =0.36 (EtOAc)。

叔丁酰胺脱水为腈示例二

     A 5 L round bottom flask was charged with N,N'-di-tert-butyl-5-(2,3-difluoro-6-nitro-phenoxy)-isophthalamide (21; 564 g) and 1.3 L of phosphorus oxychloride. The mixture was heated to between 90 deg C. ~ 100.deg. C. for 2 h, after which approximately 1/2 of the POCl 3 was removed by distillation. Toluene was added (1 L) and additional liquid was  distilled. After cooling the mixture overnight, a crude was obtained by filtration. Additional material was obtained by recovery from the mother liquid. The combined solids were stirred in MeOH (0.7 L) for between 1 and 3 h, filtered and dried in a vacuum oven between 50~80 degC. at 25 Torr with a nitrogen bleed to afford 339 g of 22 (90percent theory).

叔丁酰胺脱水为腈示例三

       At ice-water bath, oxalyl chloride (0.345 ml) was added dropwise to a solution of 1.0 g of ethyl 1-{4-[2-(t-butylaminocarbonyl)phenyl]phenyl}methyl-4-(1-hydroxy-1 methylethyl)- 2-propylimidazole-5-carboxylate in 10 ml of methylene chloride. The mixture was stirred at the same temperature for 2 hours. The reaction mixture was diluted with an aqueous solution of sodium hydrogencarbonate and ethyl acetate, and the ethyl acetate layer was

separated, dried over anhydrous magnesium sulfate and concentrated by evaporation under reduced pressure. The residue was purified by silica gel column chromatography, using 1:1 EtOAc/hex (v/v) as the eluent, to give 0.69 g of the title compound as crystals.