【J. Chem. Res., 2009 , 4 , 229- 230.】
General Procedure forDealkylation of Ether. To a 2 M solution of ether (1 equiv.) in a suitable solvent (Table 10) is added neattrimethylsilyl iodide (1.3 equiv.) through a dry syringe. The reaction is maintained at temperature indicated in Table 10 and monitored by NMR forcompletion. Yields are calculated by NMR integration of pertinent peaks. Forisolation of the alcohols, at the completion of the reaction, the excesstrimethylsilyl iodide is destroyed and the intermediate trimethylsilyl etherformed during the reaction is hydrolyzed to alcohol by pouring the reactionmixture into methanol (4 equiv.). The volatile components are removed atreduced pressure and the residue is taken up in ether, washed with aqueoussodium bisulfite, aqueous sodium bicarbonate and brine and dried. The residueleft after evaporation of solvent is further purified (if necessary) by columnchromatography on silica gel.
【M. E. Jung and M. A.Lyster, J. Org. Chem., 1977, 42, 3761】